Background: Partial nephrectomy is the preferred treatment for localized renal tumors whenever technically feasible because it preserves renal function while maintaining oncological efficacy. We report our initial institutional experience and perioperative outcomes following partial nephrectomy.

Methods: This retrospective case series included the first ten consecutive patients who underwent partial nephrectomy for localized renal tumors at a tertiary care center. Demographic, tumor, perioperative, pathological, and functional outcome data were collected and analyzed descriptively.

Results: Ten patients underwent partial nephrectomy during the study period. The mean age was 66.7 ± 9.1 years, and six patients (60%) were female. The mean tumor size was 3.8 ± 0.9 cm, with mean PADUA and RENAL nephrometry scores of 8.9 and 7.8, respectively, indicating predominantly intermediate-complexity tumors. The mean operative time was 198.7 ± 55.0 minutes, mean warm ischemia time 19.7 ± 5.1 minutes, mean estimated blood loss 370.5 ± 176.7 mL, and mean hospital stay 4.8 ± 1.9 days. Blood transfusion was required in three patients (30%). Postoperative complications included Clavien–Dindo Grade I (10%), Grade II (20%), Grade IIIa (20%), and Grade IIIb (10%). Histopathological examination revealed clear cell RCC in five patients (50%), chromophobe RCC in three (30%), and papillary RCC in two (20%), with pT1a disease in seven patients (70%) and pT1b disease in three (30%). Negative surgical margins were achieved in eight patients (80%), and trifecta was achieved in five patients (50%). At a mean follow-up of six months, the mean latest serum creatinine was 1.40 ± 0.40 mg/dL, mean estimated glomerular filtration rate was 68.5 ± 20.5 mL/min/1.73 m², and the mean decline in eGFR was 14.1%. CKD stage progression occurred in one patient (10%), whereas renal function remained stable in the remaining nine patients (90%).